“This is a remarkably powerful tool for examining the effects of essentially any mutation of interest in an intact animal, and in a fraction of the time required for earlier methods,” says Tyler Jacks, the David H. Such models could help researchers identify and test new drugs that target these mutations. They believe this technique could also be used for nearly any other type of cancer mutation that has been identified. Using this technique, which is based on CRISPR genome-editing technology, the researchers have created models of several different mutations of the cancer-causing gene Kras, in different organs.
In an advance that could help scientists make a dent in that long list of unexplored mutations, MIT researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models. However, for the vast majority of those mutations, researchers are unsure of how they contribute to cancer because there’s no easy way to study them in animal models. This section also contains links to related websites and 'Mouse Facts' provides informative descriptions of mouse biology.Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. The 'Information and Help' section includes an electronic bulletin board for the genetics research community and useful tools for software developers. In addition, MGI contains the Mouse Genome Database (MGD) which gives information on mouse genetic markers, molecular segments, phenotypes and mapping, and the Gene Expression Database (GXD) which holds gene expression data on the laboratory mouse and links to other resources. The Jax Mice database contains lists of mouse models and describes over 2000 strains of genetically defined mice for biomedical research.The Mouse Genome Informatics (MGI) database provides access to various sources of material on mouse genetics and includes an encyclopedia of the mouse genome. The site contains several databases concerning the genetics and biology of the laboratory mouse. This site provides access to various sources of information with details of career opportunities, Jackson Lab courses, conferences and industrial programs.
Established in 1996 and maintained by the Jackson Laboratory, Bar Harbor, Maine, USA.
0 kommentar(er)
